Single-use bioreactors

Pogled zemljevida Pogled tabele

Merilno mesto	Izdelek	Alternative
Nutrient feed	Proline Promass U 500 Coriolis flowmeter
Nutrient feed	Proline Promass U 500 Coriolis flowmeter
Antifoam feed	Proline Promass U 500 Coriolis flowmeter
Base and acid feed	Proline Promass U 500 Coriolis flowmeter
Raman Analyzer	Raman optic system for single use
Foam level in the bioreactor	Single-use capacitive foam detection Liquicap FTZ61
Temperature in the bioreactor	iTHERM CompactLine TM311 Compact thermometer	iTHERM CableLine TST310 Cable probe
Oxygen in the bioreactor	Digital optical oxygen sensor Memosens COS81E	Digital oxygen sensor Memosens COS22E
pH in the bioreactor	Digital pH sensor Memosens CPS61E
Optical density	Cell growth and biomass sensor OUSBT66
Media	Proline Promass U 500 Coriolis flowmeter

Pretok merjenje v: Nutrient feed

Endress+Hauser ponuja nabor analitskih instrumentov, ki so idealni za to fazo.

Ni na voljo

Product picture of Proline Promass U 500

Proline Promass U 500 Coriolis flowmeter

First single-use flowmeter for biotech applications with premium performance, cGMP compliance, and up to 4 I/Os

Splošne zahteve:

High reproducibility over a large flow range
Small quantities – dosing and batching
Suitable for measuring WFI (water for injection)
Measure changing fluids w/o readjustment
Real time density measurement with high accuracy

Tehnične zahteve:

Measuring task: Liquids
Highly viscous product, possible plugging
Process temperature: 5 to 50°C (41 to 120°F)
Density: 0.8 to 1.25 g/cm³

Pretok merjenje v: Nutrient feed

Endress+Hauser ponuja nabor analitskih instrumentov, ki so idealni za to fazo.

Ni na voljo

Proline Promass U 500 Coriolis flowmeter

First single-use flowmeter for biotech applications with premium performance, cGMP compliance, and up to 4 I/Os

Splošne zahteve:

High reproducibility over a large flow range
Small quantities – dosing and batching
Suitable for measuring WFI (water for injection)
Measure changing fluids w/o readjustment
Real time density measurement with high accuracy

Tehnične zahteve:

Measuring task: Liquids
Highly viscous product, possible plugging
Process temperature: 5 to 50°C (41 to 120°F)
Density: 0.8 to 1.25 g/cm³

Pretok merjenje v: Antifoam feed

Endress+Hauser ponuja nabor analitskih instrumentov, ki so idealni za to fazo.

Ni na voljo

Proline Promass U 500 Coriolis flowmeter

First single-use flowmeter for biotech applications with premium performance, cGMP compliance, and up to 4 I/Os

Splošne zahteve:

High reproducibility over a large flow range
Small quantities – dosing and batching
Suitable for measuring WFI (water for injection)
Measure changing fluids w/o readjustment

Tehnične zahteve:

Measuring task: Liquids
Highly viscous product, possible plugging
Process temperature: 5 to 50°C (41 to 120°F)
Density: 0.8 to 1.25 g/cm³

Pretok merjenje v: Base and acid feed

Endress+Hauser ponuja nabor analitskih instrumentov, ki so idealni za to fazo.

Ni na voljo

Proline Promass U 500 Coriolis flowmeter

First single-use flowmeter for biotech applications with premium performance, cGMP compliance, and up to 4 I/Os

Splošne zahteve:

High reproducibility over a large flow range
Small quantities – dosing and batching
Suitable for measuring WFI (water for injection)
Measure changing fluids w/o readjustment

Tehnične zahteve:

Measuring task: Liquids
Highly viscous product, possible plugging
Process temperature: 5 to 50°C (41 to 120°F)
Density: 0.8 to 1.25 g/cm³

Analiza merjenje v: Raman Analyzer

Endress+Hauser ponuja nabor analitskih instrumentov, ki so idealni za to fazo.

Raman optic system for single use

Ensure sterility and reliability for single-use biopharmaceutical development and manufacturing

Splošne zahteve:

Reliable composition analysis for quality insights

Tehnične zahteve:

Nivo merjenje v: Foam level in the bioreactor

Endress+Hauser ponuja nabor analitskih instrumentov, ki so idealni za to fazo.

Single-use capacitive foam detector Liquicap FTZ61 with self-adhesive sensor FZZ61

Single-use capacitive foam detection Liquicap FTZ61

For foam detection in single-use bioreactors without medium contact

Splošne zahteve:

Safe functionality with all kind of foams
Fast response time
Low hysteresis

Tehnične zahteve:

Measuring task: Point Level / Liquids
Highly viscous product, possible plugging
Process temperature: 5 to 50°C (41 to 120°F)
Density: 0.8 to 1.25 g/cm³

Temperatura merjenje v: Temperature in the bioreactor

Endress+Hauser ponuja nabor analitskih instrumentov, ki so idealni za to fazo.

Pt100 temperature sensor - iTHERM CompactLine TM311

iTHERM CompactLine TM311 Compact thermometer

Metric/imperial RTD 4-20 mA/IO-Link compact thermometer for industrial and hygienic applications

Alternative:

Pt100 RTD thermometer TST310 temperature cable probe

iTHERM CableLine TST310 Cable probe

Metric RTD thermometer with connecting cable for use in many process and laboratory applications

Splošne zahteve:

High accuracy and repeatability
Easy and accurate calibration in closed system

Tehnične zahteve:

Measuring task: Thermometer
Process temperature: 5 to 50°C (41 to 120°F)
Process pressure: 0 to 3 bar (0 to 43.5 psi)

Analiza merjenje v: Oxygen in the bioreactor

Endress+Hauser ponuja nabor analitskih instrumentov, ki so idealni za to fazo.

Memosens COS81E: Digital optical oxygen sensor for the life sciences and food industries

Digital optical oxygen sensor Memosens COS81E

Memosens 2.0 hygienic sensor for the life sciences and food industries

Alternative:

Memosens COS22E: Hygienic amperometric oxygen sensor

Digital oxygen sensor Memosens COS22E

Memosens 2.0 hygienic, amperometric oxygen sensor for the food and life sciences industries

Splošne zahteve:

High accuracy
Stability over the entire batch time
Easy and accurate calibration

Tehnične zahteve:

Measuring task: Oxygen
Process temperature: 5 to 50°C (41 to 120°F)
Density: 0.8 to 1.25 g/cm³

Analiza merjenje v: pH in the bioreactor

Endress+Hauser ponuja nabor analitskih instrumentov, ki so idealni za to fazo.

Memosens CPS61E - Digital pH sensor for the food industry and bioreactors in the biotech industry

Digital pH sensor Memosens CPS61E

Memosens 2.0 glass sensor for the food & beverage industry and for bioreactors in biotech industry

Splošne zahteve:

High accuracy
Fast batch readyness
Stability over the entire batch time
Resistant against protein adhesion

Tehnične zahteve:

Measuring task: pH
Process temperature: 5 to 50°C (41 to 120°F)
Density: 0.8 to 1.25 g/cm³

merjenje v: Optical density

Endress+Hauser ponuja nabor analitskih instrumentov, ki so idealni za to fazo.

The OUSBT66 NIR absorption sensor reliably monitors cell growth, biomass processes and algae systems

Cell growth and biomass sensor OUSBT66

Hygienic NIR absorption measurement in fermentation and crystallization applications

Splošne zahteve:

High accuracy
Easy and accurate calibration
Stability over the entire batch time
Resistant against product adhesion on windows

Tehnične zahteve:

Measuring task: Concentration
Process temperature: 5 to 50°C (41 to 120°F)
Density: 0.8 to 1.25 g/cm³

Pretok merjenje v: Media

Endress+Hauser ponuja nabor analitskih instrumentov, ki so idealni za to fazo.

Ni na voljo

Proline Promass U 500 Coriolis flowmeter

First single-use flowmeter for biotech applications with premium performance, cGMP compliance, and up to 4 I/Os

Splošne zahteve:

High reproducibility over a large flow range
Small quantities – dosing and batching
Suitable for measuring WFI (water for injection)
Measure changing fluids w/o readjustment

Tehnične zahteve:

Measuring task: Liquids
Highly viscous product, possible plugging
Process temperature: 5 to 50°C (41 to 120°F)
Density: 0.8 to 1.25 g/cm³

©Endress+Hauser

Key instrumentation challenges in single-use bioreactors

Fermentation in single-use bioreactors offers flexibility, fast batch turnaround and lower cross-contamination risk because cleaning and sterilization steps are largely eliminated. The biggest challenge is achieving stainless-steel-level process visibility and control with disposable, pre-installed instrumentation, while ensuring accuracy, integration, and scalability. Instrumentation is therefore critical.

Lack of standardization: There is no universal interface for sensors and controllers, creating integration challenges between bioreactor, sensor and automation suppliers.
Sensor accuracy and stability: Disposable pH and DO sensors are practical and widely used, but may offer lower accuracy and narrower operating ranges than traditional reusable probes.
Calibration and verification: Pre-calibrated sensors reduce setup effort, but users have limited possibilities for recalibration or validation once the bag is installed.
Data quality for scale-up: Reliable, reproducible measurements are essential for process control, PAT implementation and technology transfer from development to production.

Single-use portfolio highlights

Explore our innovations for your single-use fermentation process

Enostavni produkti
Lahka izbira, vgradnja in uporaba

Tehnična odličnost

Preprostost

Kaj je FLEX?

Standardni produkti
Zanesljivi, robustni, nezahtevni za vzdrževanje

Tehnična odličnost

Preprostost

Kaj je FLEX?

Vrhunski produkti
Visoko funkcionalni in praktični

Tehnična odličnost

Preprostost

Kaj je FLEX?

Specialni produkti
Zasnovani za posebej zahtevne aplikacije

Tehnična odličnost

Preprostost

Spremenljivo

Kaj je FLEX?

FLEX izbira	Tehnična odličnost	Preprostost
F L E X Segment Fundamental Zadostite svojim osnovnim merilnim potrebam	Tehnična odličnost	Preprostost
F L E X Segment Lean Obvladajte ključne procese na preprost način	Tehnična odličnost	Preprostost
F L E X Segment Extended Optimirajte procese z inovativnimi tehnologijami	Tehnična odličnost	Preprostost
F L E X Segment Xpert Imejte pod nadzorom najzahtevnejše aplikacije	Tehnična odličnost	Preprostost Spremenljivo

Spoznajte FLEX podrobneje

Proline Promass U 500 Coriolis flowmeter

First single-use flowmeter for biotech applications with premium performance, cGMP compliance, and up to 4 I/Os

Single-use capacitive foam detection Liquicap FTZ61

For foam detection in single-use bioreactors without medium contact

Raman optic system for single use

Ensure sterility and reliability for single-use biopharmaceutical development and manufacturing

Raman spectroscopy system bio multi optic

Raman bio multi optic

Optimize spectral quality for bioprocess measurement

Raman spectroscopy disposable bio sleeve for bioprocessing

Raman bio sleeve

Maintain sterility and spectral quality while reducing maintenance and cleaning burdens

Single-use technology: accelerating agile bioprocess development

Promass U 500 mounted on a skid in a biotech process

Izdelki

Single-use flow measurement in the biotech industry with Proline Promass U 500

Izdelki

Additional single-use offerings for biopharmaceutical applications

FAQ

Frequent questions on fermentation in single-use bioreactors

How is single-use compatibility managed in biopharmaceutical bioprocessing?

Single-use compatibility in biopharmaceutical bioprocessing is ensured through rigorous testing and regulatory controls. Manufacturers assess the chemical compatibility of plastic films, tubing and connectors with process fluids, while conducting extractables and leachables (E&L) studies and biocompatibility testing to verify that materials do not release harmful substances or affect cell growth, product quality or patient safety. This helps ensure reliable performance, low contamination risk and compliance with industry standards.

What is a single-use bioreactor?

A single-use bioreactor is a bioprocessing system that uses a pre-sterilized, disposable plastic bag instead of a traditional glass or stainless-steel vessel for growing cells or microorganisms. The bag is housed within a reusable support structure and is discarded after use. Key advantages include faster setup, no cleaning or sterilization requirements, and a lower risk of contamination.

How does single-use fermentation and cell culture work?

Single-use fermentation and cell culture use pre-sterilized disposable bioreactor bags instead of reusable stainless-steel or glass vessels to cultivate cells. Process fluids, nutrients and gases are fed into the closed system, where mixing, aeration, temperature, pH and dissolved oxygen are carefully controlled to support growth and product formation. Advanced sensors monitor critical process parameters, while disposable components reduce cleaning requirements, shorten setup times and lower contamination risks.

What are the critical process parameters in single-use fermentation and cell culture?

Critical process parameters (CPPs) in single-use fermentation and cell culture are key measurable variables, such as pH, dissolved oxygen (DO), and temperature, that must be monitored and controlled to maintain optimal growth conditions and ensure consistent product quality. Because CPPs directly influence critical quality attributes (CQAs), they form the foundation of process control, risk management, and quality-by-design approaches.

All single-use process maps

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Key instrumentation challenges in single-use bioreactors

Explore our innovations for your single-use fermentation process

More articles on single-use applications

Single-use technology: accelerating agile bioprocess development

Single-use flow measurement in the biotech industry with Proline Promass U 500

Additional single-use offerings for biopharmaceutical applications

Frequent questions on fermentation in single-use bioreactors

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Podjetje

Key instrumentation challenges in single-use bioreactors

Explore our innovations for your single-use fermentation process

More articles on single-use applications

Single-use technology: accelerating agile bioprocess development

Single-use flow measurement in the biotech industry with Proline Promass U 500

Additional single-use offerings for biopharmaceutical applications

Frequent questions on fermentation in single-use bioreactors

Produkti in Storitve

Panoge

Podpora

Podjetje

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