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GMP pharmaceutical manufacturing, compliant and productive

Hit quality, compliance and productivity targets with leading edge sensor technology

GMP pharmaceutical manufacturing transition from small scale process development can be challenging. Higher levels of automation and control, new instrumentation and technologies bring additional complexity. GMP compliance, industry standards and guidelines, all need to be addressed to ensure quality specifications are met. Our pharmaceutical manufacturing portfolio enables real-time monitoring and control of quality and process parameters while reaching productivity targets.

  • 100%

    matching instruments

    to user requirements - perfectly engineered, right first time

How we can help

Endress+Hauser offers a complete portfolio of scalable solutions for pharmaceutical manufacturing excellence. Our instrumentation and sensor devices enable accurate monitoring of critical process conditions, safeguarding compliance and guaranteeing batch release.

  • Bioreactor and foam level measurement and control

  • Protein separation in chromatography skids

  • Analytical measurement in both laboratory and manufacturing

  • Field instruments for easy calibration

  • Entire instrumentation designed according to the ASME BPE standard

Applications

Controlled fermentation

Involving living cells, fermentation is a very complex, sensitive and cost intensive bioprocess. Aseptic conditions must be strictly ensured throughout the biopharmaceutical manufacturing process. Consistent measurement is vital when meeting these requirements.

Controlled fermentation
Our expertise in the field

Designed for long-term stability and accuracy, our instrumentation portfolio enables complete control of bio-reactor conditions:

Efficient chromatography

Accurate measurement of conductivity and pH parameters is vital when leveraging chromatography. Moreover, detecting the target proteins to be separated from the complex mixture of the fermentation broth can be a complex challenge.

Efficient chromatography
Our expertise in the field

Our monitoring solutions enable essential chromatography conditions to be maintained to support the separation process. We also offer UV process photometer sensors to facilitate the detection of target proteins:

Stable pH measurement

In a bioreactor pH is a critical control parameter. Each cell line has its optimum pH range for efficient cell growth and protein expression. From laboratory to large scale manufacturing, consistent and reliable data is required.

Stable pH measurement
Our expertise in the field

The Endress+Hauser portfolio ensures stable inline pH measurement during fermentation for maximum reliability over all scales and allows an innovative calibration philosophy in the laboratory:

  • Leverage Memosens cutting-edge sensor technology

  • Deploy the same digital technologies in sensors and instrumentation from laboratory to large scale manufacturing

Learn how to standardize your instrumentation

bioprocess overview ©Endress+Hauser

Bioprocess overview

fermentation process ©Endress+Hauser

Fermentation process

chromatography process ©Endress+Hauser

Chromatography process

virus filtration process ©Endress+Hauser

Virus filtration process

concentration process ©Endress+Hauser

Concentration process

  • bioprocess overview
  • fermentation process
  • chromatography process
  • virus filtration process
  • concentration process

Meet our expert

"I am really happy to work for the biopharmaceutical industry at Endress+Hauser and to bring real value to your projects."

Klaus Köhler

Global Industry Manager, Endress+Hauser (Deutschland) AG+Co. KG

Benefits

Streamline your projects for the biopharmaceutical manufacturing process together with our employees, like Klaus Köhler. They provide both a complete range in instrumentation and profound industry expertise to find the best solution for your needs.

  • 80 %

    reduction of instrument type diversity

  • 2 months

    faster time to market

  • 0

    changes of instruments, thanks to right-first-time specification

Success stories

Learn why our customers choose Endress+Hauser. Check out our latest industry case studies, application notes and white papers.

  • Simple products

  • Easy to select, install and operate

Technical excellence

Simplicity

  • Standard products

  • Reliable, robust and low-maintenance

Technical excellence

Simplicity

  • High-end products

  • Highly functional and convenient

Technical excellence

Simplicity

  • Specialized products

  • Designed for demanding applications

Technical excellence

Simplicity

Variable

FLEX selections Technical excellence Simplicity
  • F
  • L
  • E
  • X

Fundamental selection

Meet your basic measurement needs

Technical excellence
Simplicity
  • F
  • L
  • E
  • X

Lean selection

Handle your core processes easily

Technical excellence
Simplicity
  • F
  • L
  • E
  • X

Extended selection

Optimize your processes with innovative technologies

Technical excellence
Simplicity
  • F
  • L
  • E
  • X

Xpert selection

Master your most challenging applications

Technical excellence
Simplicity

Variable

Browse through our portfolio!

  • Analytics - We help you to improve quality while reducing operational costs

    Analysis

    Analysis

    Water, beverages, dairy products, chemicals or pharmaceuticals have to be analyzed every day. Choose the device best suited to your process needs from our comprehensive product portfolio.

  • Flow measurement

    Flowmeter

    Flowmeter

    Water, natural gas, steam, mineral oil, chemicals are some of the fluids that have to be measured day in, day out. Select the flowmeter best suited to your process needs.

  • Field of Applications Level

    Level

    Level

    Continuous level measurement and point level detection in liquids and bulk solids

  • Field of Application Pressure

    Pressure

    Pressure

    Powerful instruments for process pressure, differential pressure, level and flow.

  • Endress+Hauser offer appropriate software solutions for all branches of industry.

    Software

    Software

    Apart from all relevant measuring and system technologies, we also offer appropriate software for all branches of industry that provide to run your operating processes at its full potential.

  • System products and Data Managers

    System products

    System products

    Applicator

  • Key visual temperature

    Temperature measurement

    Temperature measurement

    Thermometers and transmitters for the process industry

  • Improve productivity while lowering your costs. Optimize your systems and processes with solutions.

    Solutions to improve productivity while lowering your costs

    Solutions to improve productivity while lowering your costs

    With the combination of reliable instruments and systems combined with services addressing your needs we help you to overcome your challenges. Learn more about the possibilities available to you.

  • Service portfolio

    Instrumentation services

    Instrumentation services

    Maximize plant performance, minimize OPEX, increase uptime, all with compliance. Partner with Endress+Hauser instrumentation services.

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Other Industries

  • Close up picture of an engineer in a chemical plant

    Chemical: Competitive and safe

    Chemical: Competitive and safe

    Get the extra project skill and know-how you need to boost your plant's safety and performance

  • Engineer in front of a wastewater plant

    Water & Wastewater: Water is our life

    Water & Wastewater: Water is our life

    Through working with water in over 100 countries, we can help you improve plant safety and availability, optimize costs in your internal water processes and support your risk and failure management.

  • Worker with steam in the background

    Utilities: Steam and industrial water management

    Utilities: Steam and industrial water management

    Make your utilities management more efficient, safe and reliable. Rely on Endress+Hauser to improve your steam energy systems and industrial water treatment. Learn more about our offering here.

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